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However, excessive mTORC1 activation, which can be caused, for example, by high dietary intake of carbohydrates or fats, hyperinsulinemia, or inflammatory and oxidative stress, leads to activation of p70 ribosomal S6 kinase (S6K1) (115), S6K1 phosphorylates IRS-1 on serine residues, resulting in its inactivation, impaired interaction with the insulin receptor, diminished insulin signalling, and the development of insulin resistance (116)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 104.Wen Z., Yan Z., Hu K., Pang Z., Cheng X., Guo L., Zhang Q., Jiang X., Fang L., Lai R